四氢噻喃-4-酮 1,1-二氧化物合成路线 （共 19 条）
反应条件
peracetic acid in acetic acid; ethyl acetate
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2261213 A1, 2010 ;
Location in patent: Page/Page column 60 ;
EP 2261213 A1
反应条件
oxone; sodium hydrogencarbonate in acetonitrile
参考文献
Medicines for Malaria Venture MMV International Centre Cointrin
Patent: US6486199 B1, 2002 ;
反应条件
morpholine; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Ambient temperature;
参考文献
Casy, Guy; Sutherland, Alan G.; Taylor, Richard J. K.; Urben, Peter G.
Synthesis, 1989 , # 10 p. 767 - 769
反应条件
1: 79 percent / 10percent aq. H2SO4 / 3 h / Heating 2: 89 percent / peracetic acid / ethyl acetate; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 6 p. 1665 - 1673
反应条件
1: 78 percent / NaOMe / diethyl ether / 6 h / Heating 2: 79 percent / 10percent aq. H2SO4 / 3 h / Heating 3: 89 percent / peracetic acid / ethyl acetate; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 6 p. 1665 - 1673
反应条件
1: 93 percent / TsOH / toluene / Heating 2: 1.) NaH, allyl alcohol / 1.) Et2O, room temp., 15 min; 2.) reflux, 4 h 3: 78 percent / oxone, KHSO3 / H2O; methanol / Ambient temperature 4: 85 percent / morpholine / Pd(PPh3)4 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 767 - 769
反应条件
1: 1.) NaH, allyl alcohol / 1.) Et2O, room temp., 15 min; 2.) reflux, 4 h 2: 78 percent / oxone, KHSO3 / H2O; methanol / Ambient temperature 3: 85 percent / morpholine / Pd(PPh3)4 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 767 - 769
反应条件
1: 78 percent / oxone, KHSO3 / H2O; methanol / Ambient temperature 2: 85 percent / morpholine / Pd(PPh3)4 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 767 - 769
参考文献
Journal of the American Chemical Society, , vol. 70, p. 1813,1816
反应条件
1: sodium acetate; acetone 2: acetic acid; zinc-powder View Scheme
参考文献
Journal of the American Chemical Society, , vol. 70, p. 1813,1816
