FMOC-L-4-氰基苯丙氨酸合成路线 （共 4 条）
反应条件
sodium carbonate in 1,4-dioxane T=0 - 20°C; 1.5 h;
参考文献
Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Dean, Richard T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1372 - 1382
反应条件
1: 1.) NaOH, 2.) 6 M aq. HCl / 1.) EtOH, reflux, 18 h, 2.) EtOH 2: 70.7 percent / aq. LiOH / 56 h / porcine kidney acylase, pH 7.2-7.5 3: 89 percent / aq. Na2CO3 / dioxane / 1.5 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1372 - 1382
反应条件
1: 1.) EtONa / 1.) EtOH, 0-5 deg C, 45 min, 2.) EtOH, reflux, 2.5 h 2: 1.) NaOH, 2.) 6 M aq. HCl / 1.) EtOH, reflux, 18 h, 2.) EtOH 3: 70.7 percent / aq. LiOH / 56 h / porcine kidney acylase, pH 7.2-7.5 4: 89 percent / aq. Na2CO3 / dioxane / 1.5 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1372 - 1382
反应条件
1: 70.7 percent / aq. LiOH / 56 h / porcine kidney acylase, pH 7.2-7.5 2: 89 percent / aq. Na2CO3 / dioxane / 1.5 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1372 - 1382
