1,1-二乙氧基-3-甲基-2-丁烯合成路线 （共 26 条）
反应条件
3-Methylpyridine in xylene
T=118°C; 24 h;
参考文献
North, Jeffrey T.; Kronenthal, David R.; Pullockaran, Annie J.; Real, Sharon D.; Chen, Helen Y.
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3397 - 3400
反应条件
zinc(II) chloride
1) Me3N, 50-55 deg C, 3 h; r.t., 24 h, 2) EtOAc, 40 deg C, 1.5 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Makin, S. M.; Shavrygina, O. A.; Kruglikova, R. I.; Mikerin, I. E.; Tung, Nguyen Fyong; Ermakova, G. A.
Journal of Organic Chemistry USSR (English Translation), 1983 , p. 1994 - 1996
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 11 p. 2285 - 2288
反应条件
1.1: t-BuOK; BuLi / hexane; tetrahydrofuran / 2 h / -95 °C
1.2: ClSnBu3 / hexane; tetrahydrofuran / 2 h / -95 - -50 °C
1.3: 0.11 g / LiCl; CuCl / Pd(PPh3)4 / dimethylsulfoxide / 2 h / 25 °C
2.1: 86 percent / Amberlyst-15 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Tivola, Paolo Balma; Deagostino, Anna; Prandi, Cristina; Venturello, Paolo
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 4 p. 437 - 441
反应条件
3-Methylpyridine in xylene
T=118°C; 24 h;
参考文献
North, Jeffrey T.; Kronenthal, David R.; Pullockaran, Annie J.; Real, Sharon D.; Chen, Helen Y.
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3397 - 3400
反应条件
1.1: tBuOK; BuLi / tetrahydrofuran; hexane / 2 h / -95 °C
1.2: triisopropyl borate / tetrahydrofuran; hexane / -95 - 20 °C
1.3: 85 percent / toluene / 25 °C
2.1: 36 percent / K2CO3 / Pd(PPh3)4 / tetrahydrofuran / 80 °C
3.1: 75 percent / Amberlyst-15 (R) / CHCl3 / 2 h
View Scheme
参考文献
Deagostino, Annamaria; Farina, Vittorio; Prandi, Cristina; Zavattaro, Chiara; Venturello, Paolo
European Journal of Organic Chemistry, 2006 , # 15 p. 3451 - 3456
反应条件
3-Methylpyridine
T=100°C; 0.333333 h; Microwave irradiation;
参考文献
Page, Philip C. Bulman; Appleby, Louise F.; Day, David; Chan, Yohan; Buckley, Benjamin R.; Allin, Steven M.; McKenzie, Michael J.
Organic Letters, 2009 , vol. 11, # 9 p. 1991 - 1993
