3-溴-2-硝基-苯并[B]噻吩合成路线 （共 23 条）
反应条件
nitric acid in dichloromethane; trifluoroacetic acid T=0°C; 0.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14895 A1, 2004 ;
Location in patent: Page 103 ;
WO 2004/014895 A1
反应条件
triethylamine in N,N-dimethyl-formamide T=120°C;
参考文献
Cosimelli, Barbara; Lamartina, Liliana; Spinelli, Domenico
Tetrahedron, 2001 , vol. 57, # 42 p. 8903 - 8911
反应条件
triethylamine in N,N-dimethyl-formamide 0.25 h; Heating; Yield given. Yields of byproduct given;
参考文献
Cosimelli, Barbara; Lamartina, Liliana; Spinelli, Domenico
Tetrahedron, 2001 , vol. 57, # 42 p. 8903 - 8911
反应条件
triethylamine in N,N-dimethyl-formamide T=120°C; 1.33333 h;
参考文献
Cosimelli, Barbara; Lamartina, Liliana; Lanza, Camilla Zaira; Spinelli, Domenico; Spisani, Raffaella; Vegna, Federica
Tetrahedron, 2003 , vol. 59, # 36 p. 7189 - 7201
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
triethylamine in N,N-dimethyl-formamide 0.25 h; Heating; Yield given. Yields of byproduct given;
参考文献
Guerrera, Francesco; Salerno, Loredana; Lamartina, Liliana; Spinelli, Domenico
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 10 p. 1243 - 1246
反应条件
1: N,N-dimethyl-formamide / 1 h / 140 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 24 h View Scheme
参考文献
GLAXO GROUP LIMITED; BULLION, Ann, Marie; BUSCH-PETERSEN, Jakob; EVANS, Brian; NEIPP, Christopher, E.; MCCLELAND, Brent, W.; NEVINS, Neysa; WALL, Michael, D.
Patent: WO2011/25799 A1, 2011 ;
WO 2011/025799 A1
反应条件
in N,N-dimethyl-formamide T=80°C; Yield given;
参考文献
Guerrera; Salerno; Siracusa; Ronsisvalle; Caruso; Leone; Felice
Farmaco, 1990 , vol. 45, # 1 p. 29 - 38
反应条件
in ethanol; water 2.5 h; Heating;
参考文献
Bjoerk, Malin; Grivas, Spiros
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 1 p. 101 - 109
