3-(1,2,3,6-四氢-1-甲基-4-吡啶)-1H-吲哚合成路线 (共 5 条)
反应条件
potassium hydroxide in methanol 18 h; Reflux;
参考文献
NYCOMED GMBH; BARTELS, Bjoern; WEINBRENNER, Steffen; MARX, Degenhard; DIEFENBACH, Joerg; DUNKERN, Torsten; MENGE, Wiro M.P.B.; CHRISTIAANS, Johannes A. M.
Patent: WO2010/15588 A1, 2010 ;
Location in patent: Page/Page column 105-106 ;
WO 2010/015588 A1
反应条件
in acetic acid T=100°C; 1 h;
参考文献
Guillaume; Dumont; Laurent; Nedelec
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 1 p. 33 - 43
参考文献
Allelix Biopharmaceuticals Inc.
Patent: US6133287 A1, 2000 ;
US 6133287 A
参考文献
Allelix Biopharmaceuticals Inc.
Patent: US6133287 A1, 2000 ;
US 6133287 A
反应条件
1: 56 percent / 1)Borane-methyl sulfide complex 2)aq.NaOH,hydrogen peroxide / tetrahydrofuran / 1)reflux 2h 2)room temp. overnight 3)reflux 5h
2: 59 percent / Boron trifluoride ether complex / tetrahydrofuran / 48 h / Heating
View Scheme
参考文献
Freter; Fuchs
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 2 p. 377 - 379