3-(4’-哌啶基)-1H-吲哚合成路线 （共 16 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol P=2250.18 Torr; 1 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/43949 A1, 2004 ;
Location in patent: Page/Page column 30 ;
反应条件
1: With sodium methylate in methanol 2: With hydrogen; palladium dihydroxide in ethanol; acetic acid P=2068.59 Torr;
参考文献
Burm, Brigitte E.A; Gremmen, Christiaan; Wanner, Martin J; Koomen, Gerrit-Jan
Tetrahedron, 2001 , vol. 57, # 10 p. 2039 - 2049
反应条件
1: 63 percent / KOH / methanol / 5 h / 70 °C 2: 100 percent / H2; HCl / Pd/C / methanol / 1 h / 2250.18 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6326 - 6337
反应条件
1: 63 percent / KOH / methanol / 5 h / 70 °C 2: 100 percent / H2; HCl / Pd/C / methanol / 1 h / 2250.18 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6326 - 6337
反应条件
10 Pd on charcoal; hydrogen in methanol T=45°C; P=760.051 Torr; 8 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 44, # 4 p. 1710 - 1717
反应条件
1: potassium hydroxide / methanol 2: hydrogen / palladium on activated charcoal / ethanol / 20 °C View Scheme
反应条件
palladium 10 on activated carbon; hydrogen in methanol
参考文献
European Journal of Medicinal Chemistry, , vol. 63, p. 484 - 500
反应条件
1: sodium methylate / methanol 2: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 63, p. 484 - 500
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60 - 95°C; 1 h;
参考文献
NOVARTIS AG
Patent: WO2008/110611 A1, 2008 ;
Location in patent: Page/Page column 122 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=80°C; Alkylation;
参考文献
Forbes, Ian T; Cooper, David G.; Dodds, Emma K.; Hickey, Deirdre M.B.; Ife, Robert J.; Meeson, Malcolm; Stockley, Martin; Berkhout, Theo A.; Gohil, Jayneeta; Groot, Pieter H.E.; Moores, Kitty
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1803 - 1806
