N-(4,5-二甲基-3-异噁唑)氨基甲酸1,1-二甲基乙酯合成路线 （共 8 条）
反应条件
1: 3-(Boc-amino)-5-methylisoxazole With n-butyllithium in tetrahydrofuran T=-78 - 20°C; Metallation; 2: methyl iodide in tetrahydrofuran T=-78°C; Methylation;
参考文献
TORRENT PHARMACEUTICALS LTD
Patent: WO2007/100295 A1, 2007 ;
Location in patent: Page/Page column 35; 46; 57; 67; 74-75; 84; 92-93; 104; 114-115 ;
WO 2007/100295 A1
反应条件
1: 2.) aq. NaOH / 1.) pyridine, room temp., 2.) MeOH 2: n-BuLi / tetrahydrofuran / from -78 deg C up to 25 deg C 3: tetrahydrofuran / 25 °C / also with other electrophiles View Scheme
参考文献
Konoike, Toshiro; Kanda, Yasuhiko; Araki, Yoshitaka
Tetrahedron Letters, 1996 , vol. 37, # 19 p. 3339 - 3342
反应条件
1: n-BuLi / tetrahydrofuran / from -78 deg C up to 25 deg C 2: tetrahydrofuran / 25 °C / also with other electrophiles View Scheme
参考文献
Konoike, Toshiro; Kanda, Yasuhiko; Araki, Yoshitaka
Tetrahedron Letters, 1996 , vol. 37, # 19 p. 3339 - 3342
反应条件
in tetrahydrofuran T=25°C; Yield given;
参考文献
Konoike, Toshiro; Kanda, Yasuhiko; Araki, Yoshitaka
Tetrahedron Letters, 1996 , vol. 37, # 19 p. 3339 - 3342
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: EP996618 B1, 2003 ;
Location in patent: Page/Page column 5 ;
反应条件
1: TFA / 20 °C 2: pyridine / 20 °C 3: aq. NaOH / methanol / Heating View Scheme
参考文献
Kanda, Yasuhiko; Takahashi, Tadashi; Araki, Yoshitaka; Konoike, Toshiro; Mihara, Shin-ichi; Fujimoto, Masafumi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1875 - 1878
反应条件
trifluoroacetic acid T=20°C; acidolysis;
参考文献
TORRENT PHARMACEUTICALS LTD
Patent: WO2007/100295 A1, 2007 ;
Location in patent: Page/Page column 35-36; 46-47; 57; 67-68; 75; 85; 93; 104-105; 115 ;
WO 2007/100295 A1
反应条件
1: TFA / 20 °C
2: pyridine / 20 °C
View Scheme
参考文献
Kanda, Yasuhiko; Takahashi, Tadashi; Araki, Yoshitaka; Konoike, Toshiro; Mihara, Shin-ichi; Fujimoto, Masafumi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1875 - 1878
