5-甲基-4-氧代-3,4-二氢噻吩并[2,3-d]-嘧啶-6-羧酸乙酯合成路线 (共 4 条)
反应条件
acetic acid T=150°C; 40 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/42537 A1, 2005 ;
Location in patent: Page/Page column 57 ;
WO 2005/042537 A1
反应条件
1: 82 percent / sodium hydroxide / H2O / 1.5 h / Heating 2: 0.25 h / 350 °C View Scheme
参考文献
Grinev, A. N.; Kaplina, N. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 7 p. 767 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , # 7 p. 925 - 928
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=120 - 125°C; 2: With sodium hydrogencarbonate in water; toluene T=0°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/42537 A1, 2005 ;
Location in patent: Page/Page column 57 ;
WO 2005/042537 A1
反应条件
lithium hydroxide monohydrate in tetrahydrofuran; methanol; water
参考文献
PAJOUHESH, Hassan; PAJOUHESH, Hossein; DING, Yanbing; TAN, Jason; GRIMWOOD, Mike; BELARDETTI, Francesco; KAUL, Ramesh
Patent: US2008/280900 A1, 2008 ;