2-甲基-3-氧代戊酸甲酯合成路线 （共 21 条）
反应条件
triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran T=20 - 25°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 26, # 20 p. 2449 - 2452
反应条件
1.1: pyridinium tribromide; acetic acid / 20 °C 2.1: Et3N / ethyl acetate / 20 °C 3.1: 90 percent / KOH / H2O; ethanol / 3 h / 40 °C 4.1: NaH; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 0.5 h / 20 °C 4.2: BuLi / tetrahydrofuran; hexane / -78 - 20 °C 4.3: 12 percent / tetrahydrofuran; hexane / -78 - 20 °C View Scheme
参考文献
Jones, Simon M.; Urch, Jonathan E.; Brun, Reto; Harwood, John L.; Berry, Colin; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 4 p. 683 - 692
反应条件
1: methyl 3-oxo-pentanoate With potassium carbonate in tetrahydrofuran
3 h; Heating;
2: methyl iodide in tetrahydrofuran
cooling;
参考文献
Kamal, Ahmed; Shaik, Ahmad Ali; Azeeza, Shaik; Malik, M. Shaheer; Sandbhor, Mahendra
Tetrahedron Asymmetry, 2006 , vol. 17, # 20 p. 2890 - 2895
反应条件
sodium hydride in methanol; paraffin; benzene
7 h; Heating;
参考文献
Takahashi, Shunya; Oritani, Takayuki; Yamashita, Kyohei
Agricultural and Biological Chemistry, 1987 , vol. 51, # 4 p. 1143 - 1148
反应条件
1: With 1,2-dimethyl-1H-imidazole in dichloromethane
T=-45°C; 0.166667 h;
2: With tributyl-amine; titanium tetrachloride in dichloromethane
T=-45°C; 0.5 h;
参考文献
Misaki, Tomonori; Nagase, Ryohei; Matsumoto, Kunshi; Tanabe, Yoo
Journal of the American Chemical Society, 2005 , vol. 127, # 9 p. 2854 - 2855
反应条件
1: propionyl chloride With triethylamine in diethyl ether
T=20°C; 48 h;
2: methanol With sodium acetate in diethyl ether
24 h; Heating;
参考文献
Sung; Wu
Synthetic Communications, 2001 , vol. 31, # 20 p. 3069 - 3074
反应条件
water; hydrogen cation; zinc in benzene
T=40°C;
参考文献
Orsini, F.; Pelizzoni, F.; Ricca, G.
Tetrahedron Letters, 1982 , vol. 23, # 38 p. 3945 - 3948
参考文献
Johnson; Shiner
Journal of the American Chemical Society, 1953 , vol. 75, p. 1350,1354
反应条件
lithium hexamethyldisilazane in tetrahydrofuran; toluene
T=60°C; Inert atmosphere;
参考文献
Rosenbaum, Anton I.; Cosner, Casey C.; Mariani, Christopher J.; Maxfield, Frederick R.; Wiest, Olaf; Helquist, Paul
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5281 - 5289
反应条件
zinc in tetrahydrofuran
参考文献
Fouquey,C.; Jacques,J.
Synthesis, 1971 , p. 306
