2-[(2-硝基苯基)亚甲基]丙二酸二乙基酯合成路线 （共 15 条）
反应条件
ytterbium(III) triflate T=80 - 85°C; Knoevenagel condensation; 24 h; neat (no solvent);
参考文献
Ilangovan; Muralidharan; Maruthamuthu
Journal of the Korean Chemical Society, 2011 , vol. 55, # 6 p. 1000 - 1006
参考文献
Journal of the Chemical Society, , vol. 47, p. 155
反应条件
1: concentrated sulfuric acid 2: fuming nitric acid View Scheme
参考文献
Journal of the Chemical Society, , vol. 47, p. 155
反应条件
1: Raney nickel; dioxane / 95 - 105 °C / Hydrogenation 2: copper oxide-chromium oxide; dioxane / 225 °C / 147102 - 220652 Torr / Hydrogenation View Scheme
参考文献
Sauer; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 402,406
反应条件
1,4-dioxane; nickel T=95 - 105°C; Hydrogenation;
参考文献
Sauer; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 402,406
反应条件
1: 66.6 percent / Fe; AcOH / 6 h / 100 °C 2: 93 percent / aq. NaOH / methanol / 12 h / 60 °C View Scheme
参考文献
Shi, Jiandong; Xiao, Zili; Ihnat, Michael A.; Kamat, Chandrashekhar; Pandit, Bulbul; Hu, Zhigen; Li, Pui-Kai
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1187 - 1189
反应条件
sulfuric acid; water; acetic acid
参考文献
Stuart
Journal of the Chemical Society, 1885 , vol. 47, p. 155
反应条件
1: 48.5 g / H2 / Raney Ni / ethanol
2: 10.7 g / 96percent H2SO4, 70percent HNO3 / 1 h / 0 °C
3: 1.14 g / POCl3 / 2.75 h / Heating
4: 0.57 g / H2 / Raney Ni / ethanol / 22 °C / 2663.3 Torr
5: 0.17 g / CH3COOK, H2 / 20percent Pd/C / ethanol / 24 °C / 2585.7 Torr
View Scheme
参考文献
Hutt, Marland P.; MacKellar, Forrest A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 349 - 352
反应条件
1.1: acetic acid / 20 - 80 °C
1.2: 5 h / 80 - 100 °C
2.1: sodium hydride / N,N-dimethyl-formamide; ethylene glycol dimethyl ether; mineral oil / 0.25 h / 20 °C / Inert atmosphere
2.2: 0.25 h / 20 °C
2.3: 3 h / 20 - 60 °C
3.1: water; lithium hydroxide hydrate / 1,4-dioxane / 24 h / 20 °C
View Scheme
参考文献
IHARA CHEMICAL INDUSTRY CO., LTD.; KUMIAI CHEMICAL INDUSTRY CO., LTD.
Patent: US2011/287937 A1, 2011 ;
反应条件
1: 62.5 percent / iron; acetic acid / 6.5 h / 80 °C
2: 63.2 percent / sodium hydride / dimethylformamide / 8 h / 70 °C
3: 87.6 percent / 5 percent aq. NaOH / methanol / 18 h / 20 °C
View Scheme
参考文献
Suzuki; Ohuchi; Asanuma; Kaneko; Yokomori; Ito; Isobe; Muramatsu
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 2003 - 2008
