1: aq. NaOH / ethanol / 16 h / Heating 2: 94 percent / Et3N / dioxane / 16 h / 40 °C 3: 100 percent / CF3CO2H / CH2Cl2 View Scheme

sodium hydroxide in ethanol 16 h; Heating;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102551', constants.ctx, '0')">1,4-dioxane</a> <br />16&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: DMAP; pyridine / 16 h<br />2: Et₃N / 24 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 84 percent / diphenyl carbonate, sodium bicarbonate / dimethylformamide / 4.5 h / 110 - 120 &deg;C<br />2: 56 percent / DMAP / pyridine / 16 h / Ambient temperature<br />3: 39 percent / NaH / dioxane / 16 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: DMAP; pyridine / 16 h<br />2: Et₃N / 24 h / Heating<br /> <br /> &nbsp;