1: 4-(trifluoromethyl)phenol With sodium in tetrahydrofuran Heating; 2: chloromethyl methyl ether in tetrahydrofuran 1 h;

1: 93 percent / sec-butyllithium; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran; cyclohexane / 2 h / -75 °C 2: 94 percent / boron trifluoride-diethyl ether / methanol / 15 h / 25 °C View Scheme

1: 54 percent / potassium tert-butoxide; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 2: 93 percent / boron trifluoride-diethyl ether / methanol / 15 h / 25 °C View Scheme

n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane T=-75°C; 2 h;