1: 100 percent / CH2Cl2 / Ambient temperature 2: 85 percent / H2 / 5percent Pd/C / ethanol / 4 h / 3102.9 Torr / Ambient temperature 3: 1.) HCl (gas), 2.) 1 N aq. NaOH / 1.) Et2O, RT, 1 h, 2.) THF, RT, overnight View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: ethanol; H₂O / 48 h / 55 &deg;C<br />2: 1.) aq. NaOH, 2.) SOCl₂ / 1.) reflux, overnight, 2.) reflux, 3 d<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: i-Pr₂NEt / CH₂Cl₂ / Ambient temperature<br />2: 98 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 2 h / -78 &deg;C<br />3: ethanol; H₂O / 48 h / 55 &deg;C<br />4: 1.) aq. NaOH, 2.) SOCl₂ / 1.) reflux, overnight, 2.) reflux, 3 d<br /> <br /> &nbsp;