1-苯基-3-丁炔-1-醇合成路线 （共 77 条）
反应条件
tin in tetrahydrofuran; water
2 h; Ambient temperatureother aldehydes, var. time; Product distribution;
参考文献
Wu, Shihui; Huang, Bangzhou; Gao, Xiang
Synthetic Communications, 1990 , vol. 20, # 9 p. 1279 - 1286
反应条件
sodium hydroxide; 1,4-bismaleimidobutane; dihydrogen peroxide
Yield given. Multistep reaction;
参考文献
Dana, Gilbert; Figadere, Bruno; Touboul, Estera
Tetrahedron Letters, 1985 , vol. 26, # 46 p. 5683 - 5684
反应条件
palladium (II) trifluoroacetate; (+/-)-3,5,3',5'-tBu4Phbox; p-benozquinone
T=20°C;
参考文献
Motodate, Satoshi; Kobayashi, Takuya; Fujii, Mikio; Mochida, Tomoyuki; Kusakabe, Taichi; Katoh, Shigeki; Akita, Hiroyuki; Kato, Keisuke
Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2221 - 2230
反应条件
1.1: periodic acid; pyridinium chlorochromate / acetonitrile / 0 - 20 °C
2.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
3.2: 2 h / 60 °C / Inert atmosphere
4.1: zinc(II) iodide / 1,2-dichloro-ethane / 4 h / 80 °C / Inert atmosphere
5.1: NiCl2((PPh3)P)2 / toluene / 0.25 h / 20 °C / Inert atmosphere
5.2: 100 °C / Inert atmosphere
View Scheme
参考文献
Ma, Jie; Peng, Lingling; Zhang, Xiu; Zhang, Zhe; Campbell, Melody; Wang, Jianbo
Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2214 - 2220
反应条件
1: PCl5
2: NaOiPr / propan-2-ol / Heating
3: (i) EtMgHal, Et2O, (ii) /BRN= 102378/
4: H2, quinoline / Lindlar catalyst / ethyl acetate
5: (i) collidine, (ii) /BRN= 956566/, acetone
6: KNH2, liq. NH3 / pentane
7: pentane / 150 °C
View Scheme
参考文献
Marvell,E.N. et al.
Tetrahedron, 1973 , vol. 29, p. 3797 - 3806
反应条件
iron(III) chloride in dichloromethane
0.0166667 h;
参考文献
Miranda, Pedro O.; Ramirez, Miguel A.; Padron, Juan I.; Martin, Victor S.
Tetrahedron Letters, 2006 , vol. 47, # 3 p. 283 - 286
反应条件
1: phenylpropargylcarbinol With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 20°C; 1.5 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; mineral oil
T=0 - 20°C; Inert atmosphere;
参考文献
Xu, Mei; Ren, Tian-Tian; Li, Chuan-Ying
Organic Letters, 2012 , vol. 14, # 18 p. 4902 - 4905,4
反应条件
1: iPr2NH / CuBr
2: p-TsCl
3: 82 percent / LDA / tetrahydrofuran / 0.5 h
View Scheme
参考文献
Pyo, Sungsoo; Skowron III, Joseph F.; Cha, Jin K.
Tetrahedron Letters, 1992 , vol. 33, # 33 p. 4703 - 4706
反应条件
1.1: Jone's reagent / acetone / 0 °C
2.1: zinc / tetrahydrofuran / 0.25 h / 0 °C
2.2: 20 °C
3.1: sulfuric acid / dichloromethane / 0.5 h / 20 °C
View Scheme
参考文献
Xu, Haiyun; Zhang, Xinying; He, Yan; Guo, Shenghai; Fan, Xuesen
Chemical Communications, 2012 , vol. 48, # 25 p. 3121 - 3123
反应条件
1.1: Jone's reagent / acetone / 0 °C
2.1: zinc / tetrahydrofuran / 0.25 h / 0 °C
2.2: 20 °C
3.1: sulfuric acid / acetonitrile / 2 h / 40 °C
View Scheme
参考文献
Xu, Haiyun; Zhang, Xinying; He, Yan; Guo, Shenghai; Fan, Xuesen
Chemical Communications, 2012 , vol. 48, # 25 p. 3121 - 3123
