1-苯基-3-丁炔-1-醇合成路线 （共 77 条）
反应条件
1.1: Jone's reagent / acetone / 0 °C
2.1: zinc / tetrahydrofuran / 0.25 h / 0 °C
2.2: 20 °C
3.1: sulfuric acid / acetonitrile / 0.5 h / 60 °C
View Scheme
参考文献
Xu, Haiyun; Zhang, Xinying; He, Yan; Guo, Shenghai; Fan, Xuesen
Chemical Communications, 2012 , vol. 48, # 25 p. 3121 - 3123
反应条件
1: CrO3; aqueous H2SO4; acetone
2: diethyl ether
View Scheme
参考文献
Henbest
Journal of the Chemical Society, 1952 , p. 4536
反应条件
1: Mo(CO)5*Et3N / diethyl ether / 72 h / 20 °C
2: tetraphenylporphyrin; oxygen / CCl4 / 20 °C / Irradiation
3: iron(II) sulfate / H2O; CCl4
View Scheme
参考文献
Chen, Yu-Zhe; Wu, Li-Zhu; Peng, Ming-Li; Zhang, Dong; Zhang, Li-Ping; Tung, Chen-Ho
Tetrahedron, 2006 , vol. 62, # 46 p. 10688 - 10693
反应条件
1: 82 percent / PdCl2(PPh3)2, CuI, piperidine / diethyl ether / 4 h / 15 - 20 °C
2: 79 percent / Red-Al / diethyl ether; toluene / 5 h / -20 - 36 °C
3: 1.) methanesulfonyl chloride, triethylamine, 2.) DBU / 1.) CH2Cl2, room temperature, 30 min, 2.) CH2Cl2, room temperature
4: PdCl2(PhCN)2, CuI, piperidine / 1 h / Ambient temperature
5: 79 percent / Red-Al / tetrahydrofuran; toluene / Ambient temperature
6: 80 percent / MnO2 / CH2Cl2 / 1 h
View Scheme
参考文献
Crousse, Benoit; Mladenova, Margarita; Ducept, Pascal; Alami, Mouad; Linstrumelle, Gerard
Tetrahedron, 1999 , vol. 55, # 14 p. 4353 - 4368
反应条件
Iron (III) nitrate nonahydrate; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; oxygen; sodium chloride in 1,2-dichloro-ethane
T=20°C; 4 h; Reagent/catalystTimeSolvent;
参考文献
Liu, Jinxian; Ma, Shengming
Tetrahedron, 2013 , vol. 69, # 47 p. 10161 - 10167
反应条件
1: 82 percent / PdCl2(PPh3)2, CuI, piperidine / diethyl ether / 4 h / 15 - 20 °C
2: 79 percent / Red-Al / diethyl ether; toluene / 5 h / -20 - 36 °C
3: 1.) methanesulfonyl chloride, triethylamine, 2.) DBU / 1.) CH2Cl2, room temperature, 30 min, 2.) CH2Cl2, room temperature
4: 78 percent / PdCl2(PPh3)2, triethylamine / tetrahydrofuran / 4 h
View Scheme
参考文献
Crousse, Benoit; Mladenova, Margarita; Ducept, Pascal; Alami, Mouad; Linstrumelle, Gerard
Tetrahedron, 1999 , vol. 55, # 14 p. 4353 - 4368
反应条件
1: 94 percent / pyridine
2: 98 percent / N-bromosuccinimide (NBS), AgOAc
3: 18 percent / OsO4, t-BuOOH, epichlorohydrin / 2,2,4-trimethyl-pentane / 72 h / Ambient temperature
View Scheme
参考文献
Chen, Chen; Crich, David
Journal of the Chemical Society, Chemical Communications, 1991 , # 18 p. 1289 - 1290
