6-氨基-1H-吲哚-5-羧酸乙酯合成路线 （共 10 条）
反应条件
hydrogen; nickel in ethanol T=20°C; P=2585.81 Torr; 2 h;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
Title/Abstract Full Text Show Details
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
hydrogen; Raney Ni in ethanol T=20°C; 2 h;
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
Location in patent: Page/Page column 77 ;
US 20120309758 A1
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=25°C; P=3102.9 Torr; 1 h; Yield given. Yields of byproduct given;
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
1: dioxane / 1.5 h / Heating 2: H2 / Pd/C / methanol / 1 h / 25 °C / 3102.9 Torr View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 91 percent / conc. H2SO4 / 48 h / Heating 2: 30 percent / CF3SO3H, fuming HNO3 / CH2Cl2 / 20 h / 25 °C 3: dioxane / 1.5 h / Heating 4: H2 / Pd/C / methanol / 1 h / 25 °C / 3102.9 Torr View Scheme
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
1: 92 percent / conc. H2SO4 / 24 h / Heating 2: 70 percent / conc. H2SO4, fuming HNO3 / 138 h / -20 °C 3: dioxane / 1.5 h / Heating 4: H2 / Pd/C / methanol / 1 h / 25 °C / 3102.9 Torr View Scheme
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
1: 30 percent / CF3SO3H, fuming HNO3 / CH2Cl2 / 20 h / 25 °C 2: dioxane / 1.5 h / Heating 3: H2 / Pd/C / methanol / 1 h / 25 °C / 3102.9 Torr View Scheme
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
1: 70 percent / conc. H2SO4, fuming HNO3 / 138 h / -20 °C 2: dioxane / 1.5 h / Heating 3: H2 / Pd/C / methanol / 1 h / 25 °C / 3102.9 Torr View Scheme
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
1.1: nitric acid; sulfuric acid / 1.5 h / 0 - 30 °C 1.2: 2 h / Reflux 2.1: N,N-dimethyl-formamide / 5 h / 100 °C 3.1: hydrogen / Raney Ni / ethanol / 2 h / 20 °C View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
