6-氨基-1H-吲哚-7-羧酸乙酯合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=2585.7 Torr; 4 h;
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
hydrogen in ethanol P=2585.81 Torr; 2 h;
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
Location in patent: Page/Page column 78 ;
US 20120309758 A1
反应条件
1: 70 percent / dimethylformamide / 4 h / 100 °C 2: 48 percent / H2 / Pd/C / methanol / 4 h / 2585.7 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 3 p. 1155 - 1158
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 91 percent / conc. H2SO4 / 48 h / Heating 2: 31 percent / CF3SO3H, fuming HNO3 / CH2Cl2 / 20 h / 25 °C 3: 70 percent / dimethylformamide / 4 h / 100 °C 4: 48 percent / H2 / Pd/C / methanol / 4 h / 2585.7 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 3 p. 1155 - 1158
反应条件
1: 31 percent / CF3SO3H, fuming HNO3 / CH2Cl2 / 20 h / 25 °C 2: 70 percent / dimethylformamide / 4 h / 100 °C 3: 48 percent / H2 / Pd/C / methanol / 4 h / 2585.7 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 3 p. 1155 - 1158
反应条件
1: sulfuric acid; nitric acid 2: thionyl chloride; triethylamine / ethanol; ethyl acetate 3: N,N-dimethyl-formamide 4: ethanol View Scheme
反应条件
1: thionyl chloride; triethylamine / ethanol; ethyl acetate 2: N,N-dimethyl-formamide 3: ethanol View Scheme
