water; potassium carbonate in ethanol T=75°C; 17 h;

1: (COCl)2, DMF / CH2Cl2 / 0 deg C -> r.t., 18 h 2: CuI, Et3N / Pd(PPh3)2Cl2 / 15 h 3: 54 percent / diethylamine / ethanol / 24 h / Heating View Scheme

oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 0 deg C -> r.t., 18 h;

1: (COCl)2, DMF / CH2Cl2 / 0 deg C -> r.t., 18 h 2: CuI, Et3N / Pd(PPh3)2Cl2 / 15 h 3: 87 percent / diethylamine / ethanol / 24 h / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br /> <br /> &nbsp;