magnesium methanolate in methanol T=20°C; 3 h;

magnesium methanolate in methanol T=20°C;

trifluoroacetic acid T=20°C; 2 h;

1: (1S)-(+)-N-(2,2-dimethylpropionyl)-1-phenylethylamine With n-butyllithium; tert.-butyl lithium in tetrahydrofuran; hexane; pentane T=-78 - -60°C; 2: carbonic acid diethyl ester in tetrahydrofuran; hexane; pentane T=-78 - 20°C; Further stages.;

1.1: 90 percent / n-butyllithium 2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C 2.2: 86 percent / tetrahydrofuran / 1 h / -78 °C 3.1: 92 percent / magnesium methoxide / methanol / 3 h / 20 °C View Scheme

1.1: 92 percent / Et3N / CH2Cl2 / 16 h / 20 °C 2.1: n-BuLi; t-BuLi / hexane; tetrahydrofuran; pentane / -78 - -60 °C 2.2: 24 percent / hexane; tetrahydrofuran; pentane / -78 - 20 °C View Scheme