4-(4-氯苄基氨基)-3-氨基苯甲酸甲酯合成路线 （共 6 条）
反应条件
nickel dichloride; zinc in methanol Heating;
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
1: dimethylformamide / 80 °C 2: H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Goeker, Hakan; Tebrizli, Emin; Abbasoglu, Ufuk
Farmaco, 1996 , vol. 51, # 1 p. 53 - 58
反应条件
1: HCl 2: dimethylformamide / 80 °C 3: H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
1: thionyl chloride / 24 h / Reflux 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / Reflux 3: SnCl2·2H2O / ethyl acetate / 2 h / Reflux View Scheme
参考文献
Shionogi and Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru
Patent: EP2604260 A1, 2013 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / Reflux 2: SnCl2·2H2O / ethyl acetate / 2 h / Reflux View Scheme
参考文献
Shionogi and Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru
Patent: EP2604260 A1, 2013 ;
反应条件
1: 82.6 percent / dimethylformamide / 5 h / 80 °C 2: 80.6 percent / NiCl2*6H2O, Zn / methanol / 1 h / Heating View Scheme
参考文献
Goeker, Hakan; Tebrizli, Emin; Abbasoglu, Ufuk
Farmaco, 1996 , vol. 51, # 1 p. 53 - 58
