3-氮杂双环[3.1.0]己烷-6-甲酸乙酯合成路线 （共 4 条）
反应条件
hydrogen; 10 palladium hydroxide on carbon powder in methanol 1.5 h;
参考文献
WO2004/33451 A1, ;
Page 63-64 ;
反应条件
1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 °C 1.2: 0 °C / Reflux 2.1: hydrogen / palladium(II) oxide hydrate / methanol / 775.74 Torr View Scheme
参考文献
WO2012/125662 A1, ;
WO 2012/125662 A1
反应条件
1.1: sodium hydrogencarbonate / 1,4-dioxane; water 2.1: water; lithium hydroxide hydrate / methanol / 18 h / 20 °C 2.2: 0 °C / pH ~ 3 3.1: triethylamine; diphenyl phosphoryl azide / 22 h / Reflux 4.1: hydrogen / palladium(II) oxide hydrate / methanol / 2.5 h / 775.74 Torr / Inert atmosphere View Scheme
参考文献
MERCK SHARP and DOHME CORP.; NAIR, Anilkumar, G.; KOZLOWSKI, Joseph, A.; DUCA, Jose, S.; ROSENBLUM, Stuart, B.
Patent: WO2012/125662 A1, 2012 ;
WO 2012/125662 A1
反应条件
1.1: sodium hydrogencarbonate / 1,4-dioxane; water
2.1: water; lithium hydroxide hydrate / methanol / 18 h / 20 °C
2.2: 0 °C / pH ~ 3
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; NAIR, Anilkumar, G.; DUCA, Jose, S.; DWYER, Michael, P.; KOZLOWSKI, Joseph, A.; ROSENBLUM, Stuart, B.
Patent: WO2012/125661 A1, 2012 ;
WO 2012/125661 A1
