2,6-二[(4S)-4-苯基-2-恶唑啉基]吡啶合成路线 （共 8 条）
反应条件
1: With potassium hydrogencarbonate in isopropanol acetate T=80°C; Substitution; 2 h; 2: With 4-(N,N-dimethlyamino)pyridine; TEA; p-toluenesulfonyl chloride in dichloromethane T=20°C; Cyclization; 40.6667 h; Further stages.;
参考文献
Schaus; Jacobsen
Organic letters, 2000 , vol. 2, # 7 p. 1001 - 1004
反应条件
1: With triethylamine in dichloromethane T=20°C; 3 h; 2: With methanesulfonyl chloride; triethylamine in dichloromethane T=0°C; 24 h;
参考文献
Kim, Hae-Jo; Asif, Riaz; Chung, Doo Soo; Hong, Jong-In
Tetrahedron Letters, 2003 , vol. 44, # 23 p. 4335 - 4338
反应条件
1: With thionyl chloride Heating; 2: With sodium hydroxide in methanol T=20°C; 72 h;
参考文献
Redlich, Mark; Hossain, M. Mahmun
Tetrahedron Letters, 2004 , vol. 45, # 49 p. 8987 - 8990
反应条件
zinc trifluoromethanesulfonate in toluene 48 h; Heating;
参考文献
Cornejo; Fraile; Garcia; Gil; Martinez-Merino; Mayoral; Pires; Villalba
Synlett, 2005 , # 15 art. no. G13005ST, p. 2321 - 2324
反应条件
1.1: thionyl chloride / Heating 2.1: CHCl3 / 0 °C 3.1: thionyl chloride / Heating 3.2: 52 percent / aq. sodium hydroxide / methanol / 72 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 49 p. 8987 - 8990
反应条件
1: NaOCH3 / 36 h / 20 °C 2: CH2Cl2 / 48 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 27 p. 4543 - 4546
反应条件
1.1: CHCl3 / 0 °C 2.1: thionyl chloride / Heating 2.2: 52 percent / aq. sodium hydroxide / methanol / 72 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 49 p. 8987 - 8990
反应条件
in dichloromethane 48 h; Heating;
参考文献
Tetrahedron Letters, , vol. 46, # 27 p. 4543 - 4546
