反应条件
1: ethanol / 1 h / |Reflux 2: sodium hydroxide / 1 h / |Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C 4: boron trichloride / dichloromethane / 2 h / 0 - 5 °C 5: thionyl chloride / dichloromethane / 2 h / 0 - 5 °C 6: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 7: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; 1,4-dioxane / 3 h / 100 °C / |Microwave irradiation; |Inert atmosphere View Scheme
参考文献
Polucci, Paolo; Magnaghi, Paola; Angiolini, Mauro; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Bertrand, Jay; Casale, Elena; Cauteruccio, Silvia; Cirla, Alessandra; Cozzi, Liviana; Galvani, Arturo; Jackson, Peter K.; Liu, Yichin; Magnuson, Steven; Malgesini, Beatrice; Nuvoloni, Stefano; Orrenius, Christian; Sirtori, Federico Riccardi; Riceputi, Laura; Rizzi, Simona; Trucchi, Beatrice; O'Brien, Tom; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto
Journal of Medicinal Chemistry, 2013 , vol. 56, # 2 p. 437 - 450