N-Cbz-3-甲基-3-哌啶甲酸合成路线 （共 6 条）
反应条件
1: With water; lithium hydroxide hydrate in ethanol T=86°C; 1 h; 2: With potassium hydrogensulfate in water pH=3 - 4;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/140320 A1, 2009 ;
Location in patent: Page/Page column 73 ;
WO 2009/140320 A1
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
Taylor, G. Mark; Baker, Stewart J.; Gedney, Andrea; Pearson, David J.; Sibley, Graham E. M.
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1297 - 1300
反应条件
1: HCl 2: 90 percent / LiN(TMS)2, DMPU / tetrahydrofuran / -60 °C / to room temperature 3: 78 percent / NaOH / tetrahydrofuran; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 8 p. 1297 - 1300
反应条件
1: 98 percent / NaHCO3 / dioxane 2: HCl 3: 90 percent / LiN(TMS)2, DMPU / tetrahydrofuran / -60 °C / to room temperature 4: 78 percent / NaOH / tetrahydrofuran; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 8 p. 1297 - 1300
反应条件
1: 90 percent / LiN(TMS)2, DMPU / tetrahydrofuran / -60 °C / to room temperature 2: 78 percent / NaOH / tetrahydrofuran; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 8 p. 1297 - 1300
反应条件
1: 98 percent / NaHCO3 / dioxane 2: HCl 3: 90 percent / LiN(TMS)2, DMPU / tetrahydrofuran / -60 °C / to room temperature 4: 78 percent / NaOH / tetrahydrofuran; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 8 p. 1297 - 1300
