2,4-二氯-7-氟喹唑啉合成路线 （共 2 条）
反应条件
trichlorophosphate 72 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/49033 A1, 2005 ;
Location in patent: Page/Page column 113 ;
WO 2005/049033 A1
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 2-amino-4-fluorobenzonitrile in chlorobenzene T=120°C; 6 h;
参考文献
Li, Zhenhua; Wu, Danli; Zhong, Weihui
Heterocycles, 2012 , vol. 85, # 6 p. 1417 - 1426
