(E)-4-羟基他莫昔芬合成路线 （共 15 条）
反应条件
1: 85 percent / (n-Bu)4N(+)HSO4(-) / 1.) 3M aq. NaOH, reflux, 1 h, 2.) 6M aq. NaOH, reflux, 1 h 2: 94 percent / (CF3CO)2O / 70 h / 20 °C 3: 1.) Mg, BrCH2CH2Br / 1.) ether, 20 deg C, 1 h, 2.) 20 h, r.t. 4: conc. HCl / 4 h / Heating 5: 2.) MeONa / 1.) EtOH, reflux, 20 h, 2.) DMF, 30 deg C, 2 h View Scheme
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
反应条件
1: 1.) Mg, BrCH2CH2Br / 1.) ether, 20 deg C, 1 h, 2.) 20 h, r.t. 2: conc. HCl / 4 h / Heating 3: 2.) MeONa / 1.) EtOH, reflux, 20 h, 2.) DMF, 30 deg C, 2 h View Scheme
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
反应条件
1: 94 percent / (CF3CO)2O / 70 h / 20 °C 2: 1.) Mg, BrCH2CH2Br / 1.) ether, 20 deg C, 1 h, 2.) 20 h, r.t. 3: conc. HCl / 4 h / Heating 4: 2.) MeONa / 1.) EtOH, reflux, 20 h, 2.) DMF, 30 deg C, 2 h View Scheme
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
反应条件
sodium methylate 1.) EtOH, reflux, 20 h, 2.) DMF, 30 deg C, 2 h; Yield given. Multistep reaction;
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
反应条件
titanium tetrachloride; zinc in tetrahydrofuran 5 h; Heatingother reagents: TiCl3, Li; Yield given. Yields of byproduct given;
参考文献
Gauthier, Sylvain; Mailhot, Josee; Labrie, Fernand
Journal of Organic Chemistry, 1996 , vol. 61, # 11 p. 3890 - 3893
