3-(2-氯-4-氟苯基)-丙酸合成路线 （共 4 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1: 96 percent / pyridine; piperidine / 18 h / 70 °C 2: 98 percent / H2 / platinum oxide / aq. ethanol View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
参考文献
Glaxo Wellcome Inc.
Patent: US5708033 A1, 1998 ;
反应条件
1: oxalyl chloride / CH2Cl2 / 20 °C 2: aluminum chloride / CH2Cl2 / 2.5 h / Heating View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
