3-(2-氟-4-氯苯基)-丙酸合成路线 （共 4 条）
反应条件
sodium hydroxide in ethanol T=20°C; 6 h;
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1: 38.3 g / H2 / platinum oxide hydrate / aq. ethanol 2: 73 percent / aq. NaOH / ethanol / 6 h / 20 °C View Scheme
参考文献
Glaxo Wellcome Inc.
Patent: US5708033 A1, 1998 ;
反应条件
1: 68 percent / pyridine / CH2Cl2 / 60 h / 20 °C 2: triethylamine; bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 12 h / 110 °C 3: 38.3 g / H2 / platinum oxide hydrate / aq. ethanol 4: 73 percent / aq. NaOH / ethanol / 6 h / 20 °C View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1: oxalyl chloride / CH2Cl2 / 4 h / 20 °C 2: 4.1 g / aluminum chloride / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
