3-(2-溴-4-氟苯)丙酸合成路线 （共 4 条）
反应条件
1: With potassium hydroxide 4.5 h; Heating; 2: With sulfuric acid 18 h; Heating; Further stages.;
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1.1: 62 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 18 h / Heating; IR illumination 2.1: sodium hydride / 1,2-dimethoxy-ethane / 1 h / 20 °C 2.2: 40 percent / 1,2-dimethoxy-ethane / 1.5 h / Heating 3.1: aq. KOH / 4.5 h / Heating 3.2: 91 percent / aq. H2SO4 / 18 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 3 p. 409 - 416
反应条件
1.1: sodium hydride / 1,2-dimethoxy-ethane / 1 h / 20 °C 1.2: 40 percent / 1,2-dimethoxy-ethane / 1.5 h / Heating 2.1: aq. KOH / 4.5 h / Heating 2.2: 91 percent / aq. H2SO4 / 18 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 3 p. 409 - 416
反应条件
1: oxalyl chloride / CH2Cl2 / 18 h / 20 °C 2: aluminum chloride / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
