5-氨基-3-甲基-1,2,4-噻二唑合成路线 （共 10 条）
反应条件
in methanol T=0 - 20°C; 12 h;
参考文献
LegoChem Biosciences, Inc.; CHO, Young Lag; YUN, Joung Yul; PARK, Chul Soon; CHAE, Sang Eun; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; KANG, Dae Hyuck; YANG, Young Jae; KWON, Hyun Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu
Patent: EP2706062 A2, 2014 ;
Location in patent: Paragraph 0199 ;
反应条件
in methanol; ethyl acetate
参考文献
Gazzetta Chimica Italiana, , vol. 107, p. 1 - 5
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 36, p. 4091 - 4098
反应条件
bromine; sodium methylate anschliessendes Behandeln mit Kalium-thiocyanat;
参考文献
Chemische Berichte, , vol. 87, p. 68,74
Chemische Berichte, , vol. 89, p. 1534,1540
反应条件
T=-10°C; anschliessendes Behandeln mit Kaliumthiocyanat;
参考文献
Chemische Berichte, , vol. 87, p. 68,74
Chemische Berichte, , vol. 89, p. 1534,1540
反应条件
hydrogen bromide; copper; sodium nitrite
参考文献
Goerdeler et al.
Chemische Berichte, 1956 , vol. 89, p. 1534,1540
反应条件
aluminium trichloride
T=80 - 110°C;
参考文献
Akiba,K. et al.
Journal of the American Chemical Society, 1979 , vol. 101, # 19 p. 5857 - 5858
反应条件
1,3-dibromo-propane
1.) 130 deg C, 30 min, 2.) room temperature, overnight; Yield given. Yields of byproduct given;
参考文献
Lai, Long-Li; Ngoi, Tak-Ho; Reid, David H.; Nicol, Robin H.; Rhodes, Jane B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , p. 1753 - 1760
参考文献
Pentimalli,L. et al.
Gazzetta Chimica Italiana, 1977 , vol. 107, p. 1 - 5
