(2-(苄基氨基)乙基)氨基甲酸叔丁酯合成路线 （共 16 条）
反应条件
1: in methanol T=20°C; Molecular sieve; 2: With methanol; sodium tetrahydroborate T=-10 - 20°C; 16 h;
参考文献
PHARMACOFORE, INC.; JENKINS, Thomas, E.; HUSFELD, Craig, O.; SEROOGY, Julie, D.; WRAY, Jonathan, W.
Patent: WO2011/133150 A1, 2011 ;
Location in patent: Page/Page column 299-300 ;
反应条件
in methanol T=20°C; 72 h;
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2012/4549 A1, 2012 ;
Location in patent: Page/Page column 53 ;
反应条件
sodium tetrahydroborate; benzaldehyde; molecular sieve in methanol; ethyl acetate
参考文献
Jenkins, Thomas E.; Husfeld, Craig O.; Seroogy, Julie D.; Wray, Jonathan W.
Patent: US2011/262359 A1, 2011 ;
US 20110262359 A1
反应条件
potassium iodide in ethanol T=50°C;
参考文献
Li, Hongbo; Hao, Meng-An; Wang, Liping; Liang, Wu; Chen, Kai
Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 301 - 307
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=-20°C; Acylation; 5 h;
参考文献
Yasuhara, Tomohisa; Nagaoka, Yasuo; Tomioka, Kiyoshi
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 16 p. 2233 - 2234
反应条件
1.1: 65 percent / CH2Cl2 / 16 h / 20 °C 2.1: molecular sieves 3 Angstroem / methanol / 4 h / 20 °C 2.2: 61 percent / NaBH4 / methanol / 16 h / -5 °C View Scheme
参考文献
Yasuhara, Tomohisa; Nagaoka, Yasuo; Tomioka, Kiyoshi
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 16 p. 2233 - 2234
反应条件
1: 96 percent / HOBt*H2O, EDS*HCl / dimethylformamide / 0 °C 2: 61 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
1: 96 percent / HOBt*H2O, EDS*HCl / dimethylformamide / 0 °C 2: 61 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
borane-ammonia in ethanol Irradiation; Yield given;
参考文献
Hamada, Tatsuo; Nishida, Atsushi; Yonemitsu, Osamu
Tetrahedron Letters, 1989 , vol. 30, # 32 p. 4241 - 4244
反应条件
1: triethylamine / chloroform / 16 h / 5 - 20 °C / Sealed tube 2: hydrogen / 20 palladium(II) hydroxide on carbon / water; methanol / 2.5 h View Scheme
