(2-(苄基氨基)乙基)氨基甲酸叔丁酯合成路线 （共 16 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; Decarboxylation; 1.5 h;
参考文献
Journal of Organometallic Chemistry, , vol. 611, # 1-2 p. 586 - 592
反应条件
1: 100 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h 2: 91.3 percent / H2 / Pd/C / methanol / 4 h / 3102.9 Torr / Ambient temperature 3: 80 percent / aq. Et3N / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
反应条件
potassium tert-butylate in tetrahydrofuran T=60°C; 3 h;
参考文献
Thanigaimalai; Lee, Ki-Cheul; Bang, Seong-Cheol; Lee, Jee-Hyun; Yun, Cheong-Yong; Roh, Eunmiri; Hwang, Bang-Yeon; Kim, Youngsoo; Jung, Sang-Hun
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1135 - 1142
反应条件
triethylamine in chloroform
T=5 - 20°C; 16 h; Sealed tube;
参考文献
PHARMACOFORE, INC.; JENKINS, Thomas, E.; HUSFELD, Craig, O.; SEROOGY, Julie, D.; WRAY, Jonathan, W.
Patent: WO2011/133150 A1, 2011 ;
Location in patent: Page/Page column 300 ;
反应条件
1: With water; sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=20°C; 16 h;
2: With sodium hydrogencarbonate in water; 1,2-dichloro-ethane
参考文献
Milne, Jill C.; Jirousek, Michael R.; Bemis, Jean E.; Smith, Jesse J.
Patent: US2010/41748 A1, 2010 ;
Location in patent: Page/Page column 120 ;
反应条件
1: 90 percent / DIEA / dimethylformamide / 0 - 20 °C
2: 70 percent / ammonium formate / Pd/C / methanol / 16 h / Heating
View Scheme
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
