Fmoc-nglu(otbu)-oh [Fmoc-n-(叔丁氧基羰基乙基)-甘氨酸]合成路线 （共 5 条）
反应条件
triethylamine in acetonitrile 4 h; Ambient temperature;
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
反应条件
1: H2 / Pd/C / methanol; acetic acid / 4 h / 3102.9 Torr / Ambient temperature 2: 1.) Et3N, MgSO4, 2.) NaBH4 / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h) 3: 91.1 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h 4: 89.2 percent / H2 / Pd/C / methanol / 4 h / 3102.9 Torr 5: 76.9 percent / aq. Et3N / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
反应条件
1: 1.) Et3N, MgSO4, 2.) NaBH4 / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h) 2: 91.1 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h 3: 89.2 percent / H2 / Pd/C / methanol / 4 h / 3102.9 Torr 4: 76.9 percent / aq. Et3N / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
反应条件
1: 91.1 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h 2: 89.2 percent / H2 / Pd/C / methanol / 4 h / 3102.9 Torr 3: 76.9 percent / aq. Et3N / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
反应条件
sodium hydrogencarbonate T=20°C; 18 h;
参考文献
De Cola, Chiara; Fiorillo, Gaetano; Meli, Alessandra; Aime, Silvio; Gianolio, Eliana; Izzo, Irene; De Riccardis, Francesco
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 3 p. 424 - 431
