(S)-(-)-N-苄基-1-苯基-乙胺合成路线 （共 37 条）
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>86, p. 284,287
反应条件
1: (S)-N-benzyl-α-methylbenzylamine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: tert-butyl cinnamoate in tetrahydrofuran; hexane T=-78°C; 2 h; Inert atmosphere; 3: With water; ammonium chloride in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere; optical yield given as percent dediastereoselective reaction;
参考文献
Davies, Stephen G.; Foster, Emma M.; McIntosh, Catherine R.; Roberts, Paul M.; Rosser, Timothy E.; Smith, Andrew D.; Thomson, James E.
Tetrahedron Asymmetry, 2011 , vol. 22, # 10 p. 1035 - 1050
反应条件
1: (S)-N-benzyl-α-methylbenzylamine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: tert-butyl cinnamate in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 3: With ammonium chloride in tetrahydrofuran; hexane; water T=-78 - 0°C; optical yield given as percent dediastereoselective reaction;
参考文献
Duggan, Peter J.; Johnston, Martin; March, Taryn L.
Journal of Organic Chemistry, 2010 , vol. 75, # 21 p. 7365 - 7372
反应条件
1: (S)-N-benzyl-α-methylbenzylamine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: tert-butyl cinnamate in tetrahydrofuran; hexane T=-78°C; 2 h; 3: (S)-4-benzyl-3-(6-(benzyloxy)hex-2-enoyl)oxazolidin-2-one in tetrahydrofuran; hexane T=-78 - 0°C; 2 h; Further stages.;
参考文献
Davies, Stephen G.; Roberts, Paul M.; Smith, Andrew D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1405 - 1415
反应条件
[Ir(η5-C5Me5)(C6H4-2-C3H5N2)(NCCH3)](PF6) in N-dodecane; toluene T=100°C; 0.25 h; Inert atmosphere;
参考文献
Blacker, A. John; Stirling, Matthew J.; Page, Michael I.
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 642 - 648
反应条件
1: (S)-N-benzyl-α-methylbenzylamine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: crotonic acid isopropyl ester in tetrahydrofuran; hexane
T=-78°C; 2 h;
3: (4E)-ethyl 2-ethoxycarbonyl-5-phenyl-2,4-pentadienoate in tetrahydrofuran; hexane
T=-78 - 0°C; 2 h; Further stages.;
参考文献
Davies, Stephen G.; Roberts, Paul M.; Smith, Andrew D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1405 - 1415
反应条件
1: (S)-N-benzyl-α-methylbenzylamine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: tert-butyl cinnamate in tetrahydrofuran; hexane
T=-78°C; 2 h;
3: (4E)-ethyl 2-ethoxycarbonyl-5-phenyl-2,4-pentadienoate in tetrahydrofuran; hexane
T=-78 - 0°C; 2 h; Further stages.;
参考文献
Davies, Stephen G.; Roberts, Paul M.; Smith, Andrew D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1405 - 1415
