bis(η3-allyl-μ-chloropalladium(II)); R,R-C52H44N2O2P2 chiral ligand; sodium carbonate in dichloromethane 14 h; Ambient temperature;

O,O'-((S)-1,1'-binaphthyl-2,2'-diyl)-N,N'-di-(S,S)-(1-naphthalen-1-yl)-ethyl-phosphoramidite; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine in tetrahydrofuran T=20°C; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

tetrabutyl-ammonium chloride; lithium carbonate; bis(η3-allyl-μ-chloropalladium(II)) in toluene T=40°C; Substitution; 40 h; Title compound not separated from byproducts;

di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine; (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-[(1S)-1-(2-methoxy-phenyl)ethyl]amine in tetrahydrofuran T=20°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

sodium carbonate; (R,R)-DACH-naphthyl Trost ligand; bis(η3-allyl-μ-chloropalladium(II)) in dichloromethane Ambient temperature; Yields of byproduct given;

(R)-C4-TunePhos; sodium carbonate; [(ν3-allyl)PdCl]2 in tetrahydrofuran T=25°C; Product distribution; Further Variations:ReagentsSolventsTemperatures;