反应条件
1.1: 82 percent / HCl / dioxane; N,N-dimethyl-acetamide / 0.67 h / 90 °C 2.1: pentafluorophenyl trifluoroacetate; pyridine / dimethylformamide / 0.5 h / 20 °C 2.2: 94 percent / dimethylformamide / 20 - 90 °C 3.1: 59 percent / potassium iodide / N,N-dimethyl-acetamide / 50 °C 4.1: tetrazole / dimethylformamide / 20 °C 4.2: 63 percent / aq. hydrogen peroxide / dimethylformamide / 2 h / 20 °C 5.1: 99 percent / HCl / dioxane / 20 - 45 °C 6.1: 73 percent / cyclohexene oxide / methanol / 20 °C View Scheme
参考文献
Mortlock, Andrew A.; Foote, Kevin M.; Heron, Nicola M.; Jung, Frederic H.; Pasquet, Georges; Lohmann, Jean-Jacques M.; Warin, Nicolas; Renaud, Fabrice; De Savi, Chris; Roberts, Nicola J.; Johnson, Trevor; Dousson, Cyril B.; Hill, George B.; Perkins, David; Hatter, Glenn; Wilkinson, Robert W.; Wedge, Stephen R.; Heaton, Simon P.; Odedra, Rajesh; Keen, Nicholas J.; Crafter, Claire; Brown, Elaine; Thompson, Katherine; Brightwell, Stephen; Khatri, Liz; Brady, Madeleine C.; Kearney, Sarah; McKillop, David; Rhead, Steve; Parry, Tony; Green, Stephen
Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2213 - 2224
