2-甲基-4-氨基-6-氯嘧啶合成路线 （共 12 条）
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.25 h; 2: With di-tert-butyl dicarbonate T=20°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/66061 A1, 2012 ;
Location in patent: Page/Page column 113-114 ;
WO 2012/066061 A1
反应条件
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16.5 h / 100 °C / |Inert atmosphere; |Sealed tube
2: hydrogen; 20 palladium(II) hydroxide on carbon / methanol / 15.25 h / 20 - 25 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; WEINSTEIN, David S.; WROBLESKI, Stephen T.; TOKARSKI, John S.; KUMAR, Amit
Patent: WO2014/74661 A1, 2014 ;
