1-苯基-1,2-二氢异喹啉-3(4H)-酮合成路线 （共 17 条）
反应条件
1: 70 percent / POCl3 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., 15 h
2: 70 percent / 2 N aq. H2SO4, KMnO4 / 2 h / Ambient temperature
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参考文献
Bartmann, W.; Konz, E.; Rueger, W.
Synthesis, 1988 , # 9 p. 680 - 683
反应条件
1: 76 percent / PCl5 / 2 h / 115 - 120 °C
2: 84 percent / bis-(2-methoxy-ethyl) ether / 17 h / 160 °C
3: 83 percent / H2, NH3 / 10percent Pd/C / methanol / 12 h / 750.06 Torr / Ambient temperature
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参考文献
Renger, B.; Konz, E.; Rueger, W.
Synthesis, 1988 , # 9 p. 683 - 685
反应条件
potassium permanganate in water
1.) 70 deg C, 1 h, 2.) 100 deg C, 30 min;
参考文献
Hazai, Laszlo; Deak, Gyula
Acta Chimica Hungarica, 1986 , vol. 121, # 3 p. 237 - 242
反应条件
n-Butyl nitrite; potassium tert-butylate in toluene
T=0 - 5°C;
参考文献
Tikk, I.; Deak, Gy.; Toth, G.
Acta Chimica Hungarica, 1983 , vol. 114, # 1 p. 69 - 78
反应条件
With phosphorus pentachloride T=115 - 120°C; 2 h;
参考文献
Renger, B.; Konz, E.; Rueger, W. Synthesis, 1988 , # 9 p. 683 - 685
反应条件
Multi-step reaction with 2 steps 1: 76 percent / PCl5 / 2 h / 115 - 120 °C2: 84 percent / bis-(2-methoxy-ethyl) ether / 17 h / 160 °C
参考文献
Renger, B.; Konz, E.; Rueger, W. Synthesis, 1988 , # 9 p. 683 - 685
反应条件
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; iodine / tetrahydrofuran / 16 h / |Inert atmosphere; |Reflux2: hydrogenchloride; borane-ammonia complex / aq. phosphate buffer / 37 °C / pH 7.83: triethylamine / tetrahydrofuran / 2 h / 0 - 25 °C / |Inert atmosphere
参考文献
Ghislieri, Diego; Green, Anthony P.; Pontini, Marta; Willies, Simon C.; Rowles, Ian; Frank, Annika; Grogan, Gideon; Turner, Nicholas J. Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10863 - 10869
