2,4,6-三氨基-5-氯喹唑啉合成路线 （共 4 条）
反应条件
platinum in ethanol; 2-methoxy-ethanol
参考文献
FMC Corporation
Patent: US5534518 A1, 1996 ;
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite 1.) 2 deg C, 20 min, 2.) H2O, a) 2 deg C, 35 min, b) from RT to 55 deg C, 100 min; Yield given. Multistep reaction;
参考文献
Rosowsky; Mota; Wright; Queener
Journal of Medicinal Chemistry, 1994 , vol. 37, # 26 p. 4522 - 4528
反应条件
1: 1.) aq. HNO2, aq. HCl, 2.) SO2, HOAc, CuCl2*2H2O / 1.) 0 deg C, 20 min, 2.) water, from 0 deg C to RT, 1 h
2: H2O / 1.5 h / Heating
View Scheme
参考文献
Elslager; Colbry; Davoll; Hutt; Johnson; Werbel
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1740 - 1743
反应条件
1: 1.) aq. HNO2, aq. HCl, 2.) SO2, HOAc, CuCl2*2H2O / 1.) 0 deg C, 20 min, 2.) water, from 0 deg C to RT, 1 h
2: H2O / 1.5 h / Heating
View Scheme
参考文献
Elslager; Colbry; Davoll; Hutt; Johnson; Werbel
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1740 - 1743
