N-羟基-2-甲基苯甲酰胺合成路线 （共 8 条）
反应条件
sodium hydroxide; hydroxylamine hydrochloride in methanol; water T=40°C;
参考文献
Griffith, Darren; Krot, Krystyna; Comiskey, Jedd; Nolan, Kevin B.; Marmion, Celine J.
Dalton Transactions, 2008 , # 1 p. 137 - 147
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid in dichloromethane; N,N-dimethyl-formamide
参考文献
DuPont Pharmaceuticals Company
Patent: US6281352 B1, 2001 ;
US 6281352 B1
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
参考文献
DuPont Pharmaceuticals Company
Patent: US6281352 B1, 2001 ;
US 6281352 B1
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide
参考文献
DuPont Pharmaceuticals Company
Patent: US6281352 B1, 2001 ;
US 6281352 B1
反应条件
hydroxylamine hydrochloride; sodium hydrogencarbonate in water; ethyl acetate T=20°C; 0.0833333 h;
参考文献
Gao, Xi-Ai; Wang, Xian-Xue; Yan, Hao; Li, Jian; Yan, Ru-Long; Huang, Guo-Sheng
Journal of the Indian Chemical Society, 2013 , vol. 90, # 3 p. 381 - 385
反应条件
NMM; benzotriazol-1-ol; 1,2-dichloro-ethane in methanol; water; N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: US5952320 A1, 1999 ;
US 5952320 A
反应条件
1: thionyl chloride / 60 - 80 °C 2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethyl acetate; water / 0.08 h / 20 °C View Scheme
参考文献
Feng, Chao; Loh, Teck-Peng
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2722 - 2726
Angew. Chem., 2014 , vol. 126, # 10 p. 2760 - 2764,5
反应条件
potassium carbonate in dimethyl sulfoxide T=90°C; Lossen rearrangement; 2 h;
参考文献
Hoshino, Yujiro; Okuno, Moriaki; Kawamura, Eri; Honda, Kiyoshi; Inoue, Seiichi
Chemical Communications, 2009 , # 17 p. 2281 - 2283
