1-苯基-5-丙基-吡唑-4-羰酰氯合成路线 （共 3 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0°C; 2 h;
参考文献
Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047
反应条件
1: 80 percent / aq. NaOH / methanol / 2 h / Heating
2: 100 percent / oxalyl chloride; DMF / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047
反应条件
1: 50 percent / ethanol / 1.5 h / Heating
2: 75 percent / ethanol / 2.5 h / Heating
3: 80 percent / aq. NaOH / methanol / 2 h / Heating
4: 100 percent / oxalyl chloride; DMF / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047
