3-乙氧甲酰-1,1,1-三氟己烷-2,5-二酮合成路线 （共 5 条）
反应条件
1: ethyl-α,α,α-trifluoroacetate With sodium hydride in ethylene glycol dimethyl ether T=0 - 20°C; 0.5 h; 2: chloroacetone With potassium iodide in ethylene glycol dimethyl ether Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1362846 A1, 2003 ;
Location in patent: Page/Page column 125 ;
EP 1362846 A1
反应条件
sodium hydride in ethylene glycol dimethyl ether 17 h; Heating;
参考文献
Smith, Jonathan O.; Mandal, Braja K.; Filler, Robert; Beery, James W.
Journal of Fluorine Chemistry, 1997 , vol. 81, # 2 p. 123 - 128
反应条件
sodium hydride in benzene
参考文献
Begue, Jean-Pierre; Bonnet-Delpon, Daniele; Dogbeavou, Anukwadey
Journal of Fluorine Chemistry, 1991 , vol. 54, # 1-3 p. 279
反应条件
toluene-4-sulfonic acid in toluene Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1362846 A1, 2003 ;
Location in patent: Page/Page column 125 ;
EP 1362846 A1
反应条件
1: 73 percent / aq. NaCl / dimethylsulfoxide / 2.5 h / 110 °C 2: 42 percent / p-TsOH / toluene / 55 h / Heating View Scheme
参考文献
Smith, Jonathan O.; Mandal, Braja K.; Filler, Robert; Beery, James W.
Journal of Fluorine Chemistry, 1997 , vol. 81, # 2 p. 123 - 128
