3-甲氧基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 6 条）
反应条件
caesium carbonate; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=120°C; 8 h;
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1555018 A1, 2005 ;
Location in patent: Page/Page column 123 ;
反应条件
palladium diacetate; sodium carbonate in water; acetone T=35°C; Suzuki coupling; 1 h;
参考文献
Forghieri, Marco; Laggner, Christian; Paoli, Paolo; Langer, Thierry; Manao, Giampaolo; Camici, Guido; Bondioli, Lucia; Prati, Fabio; Costantino, Luca
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 7 p. 2658 - 2672
参考文献
Otsuka Pharmaceuticals Co., Ltd.
Patent: US6335327 B1, 2002 ;
Location in patent: Page column 92 ;
参考文献
Otsuka Pharmaceuticals Co., Ltd.
Patent: US6335327 B1, 2002 ;
Location in patent: Page column 92 ;
反应条件
1: With sodium hydroxide; water in methanol 1 h; Heating / reflux; 2: With hydrogenchloride in methanol; water
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1555018 A1, 2005 ;
Location in patent: Page/Page column 123 ;
反应条件
1: With boron tribromide in dichloromethane
T=0 - 20°C; 24 h;
2: With water in dichloromethane
Cooling with ice;
参考文献
Forghieri, Marco; Laggner, Christian; Paoli, Paolo; Langer, Thierry; Manao, Giampaolo; Camici, Guido; Bondioli, Lucia; Prati, Fabio; Costantino, Luca
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 7 p. 2658 - 2672
