4-(2-氧代-1-哌啶)-苯甲酸合成路线 （共 7 条）
反应条件
sodium hydroxide in methanol 48 h; Heating;
参考文献
Bassoli, Angela; Borgonovo, Gigliola; Busnelli, Gilberto; Morini, Gabriella
European Journal of Organic Chemistry, 2006 , # 7 p. 1656 - 1663
反应条件
1: 66 percent / NaH / tetrahydrofuran / 4 h / 20 °C 2: 57 percent / aq. NaOH / methanol / 48 h / Heating View Scheme
参考文献
Bassoli, Angela; Borgonovo, Gigliola; Busnelli, Gilberto; Morini, Gabriella
European Journal of Organic Chemistry, 2006 , # 7 p. 1656 - 1663
反应条件
1: 89 percent / pyridine / toluene / 0 °C 2: 66 percent / NaH / tetrahydrofuran / 4 h / 20 °C 3: 57 percent / aq. NaOH / methanol / 48 h / Heating View Scheme
参考文献
Bassoli, Angela; Borgonovo, Gigliola; Busnelli, Gilberto; Morini, Gabriella
European Journal of Organic Chemistry, 2006 , # 7 p. 1656 - 1663
反应条件
1: 89 percent / pyridine / toluene / 0 °C 2: 66 percent / NaH / tetrahydrofuran / 4 h / 20 °C 3: 57 percent / aq. NaOH / methanol / 48 h / Heating View Scheme
参考文献
Bassoli, Angela; Borgonovo, Gigliola; Busnelli, Gilberto; Morini, Gabriella
European Journal of Organic Chemistry, 2006 , # 7 p. 1656 - 1663
反应条件
1: K2CO3; CuI; 1,10-phenanthroline / dimethylsulfoxide / 120 - 125 °C 2: NaOH / methanol / 20 - 50 °C View Scheme
参考文献
Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; King, Sarah R.; Wang, Tammy C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y.S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4419 - 4427
反应条件
1: K2CO3; CuI; 1,10-phenanthroline / dimethylsulfoxide / 120 - 125 °C 2: NaOH / methanol / 20 - 50 °C View Scheme
参考文献
Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; King, Sarah R.; Wang, Tammy C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y.S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4419 - 4427
反应条件
sodium hydroxide; sulfuric acid
参考文献
Astrazeneca AB
Patent: US6479497 B1, 2002 ;
US 6479497 B1
