3-甲氧基-[1,1-联苯]-4-羧酸合成路线 （共 3 条）
反应条件
1: With sodium hydroxide; water in methanol 1 h; Heating / reflux; 2: With hydrogenchloride in methanol; water
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1555018 A1, 2005 ;
Location in patent: Page/Page column 123 ;
反应条件
Jone's reagent in acetone T=0°C;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 103-104 ;
WO 2010/115736 A2
反应条件
1: methyl 4-bromo-2-(methyloxy)benzoate With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide 0.166667 h; Inert atmosphere; 2: 3,4,5-trimethoxyphenylboronic acid With sodium carbonate in water; N,N-dimethyl-formamide T=80°C; 72 h;
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
Location in patent: Page/Page column 59 ;
