5-(三氟甲氧基)吲哚-2-羧酸合成路线 （共 3 条）
反应条件
lithium hydroxide; water in trans-1,3-dioxane T=25°C; 15 h;
参考文献
The Scripps Research Institute
Patent: US2005/26987 A1, 2005 ;
Location in patent: Page 22 ;
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide T=105°C; 4 h; Inert atmosphere;
参考文献
Robertson, William M.; Kastrinsky, David B.; Hwang, Inkyu; Boger, Dale L.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2722 - 2725
反应条件
1: iodine; silver sulphate / ethanol / 25 °C / Darkness 2: 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 9 p. 2722 - 2725
