1-N-BOC-4-哌啶乙酸甲酯合成路线 （共 8 条）
反应条件
palladium monocarbide in ethanol
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 121-122 ;
反应条件
1: diethyl methoxycarbonylmethyl-phosphonate With potassium hexamethylsilazane in tetrahydrofuran 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=65°C; 3: With water; hydrogen; ammonium chloride; palladium 10 on activated carbon more than 3 stages;
参考文献
US2007/10513 A1, ;
Page/Page column 29 ;
US 20070010513 A1
反应条件
tellurium; Bi(NO3)3·5H2O; 5 palladium on charcoal; oxygen in methanol T=60°C; P=760.051 Torr; 8 h;
参考文献
Powell, Adam B.; Stahl, Shannon S.
Organic Letters, 2013 , vol. 15, # 19 p. 5072 - 5075
反应条件
methanol in hexanes T=0 - 20°C; 0.5 h;
参考文献
WO2007/145563 A1, ;
Page/Page column 62 ;
WO 2007/145563 A1
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran; water
参考文献
Chee, Jennifer; Johanson, Jill N.; Kayser, Frank; Parsons, William H.; Rupprecht, Kathleen M.
Patent: US2002/13348 A1, 2002 ;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
1: lithium hexamethyldisilazane 2: sodium azide / N,N-dimethyl-formamide 3: 5 Pd(II)/C(eggshell); hydrogen View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; LANTER, James, C.; MARKOTAN, Thomas, P.; SUBASINGHE, Nalin; SUI, Zhihua; ZHANG, Xuqing
Patent: WO2012/75115 A1, 2012 ;
WO 2012/075115 A1
