6-氯-5-氰基-2-(三氟甲基)烟酸乙酯合成路线 （共 3 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=50°C; Heating / reflux; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2008/4943 A1, 2008 ;
Location in patent: Page/Page column 54-55 ;
WO 2008/004943 A1
反应条件
1: sodium ethanolate / ethanol / 16 h / 20 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 2877 - 2881
反应条件
1: acetic anhydride / 7 h / 120 - 140 °C 2: sodium ethanolate / ethanol / 16 h / 20 °C 3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 2877 - 2881
