1: With acetic acid T=20°C; 2: With N-bromosuccinmide in acetic acid T=0 - 5°C;

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine / 36 h / 100 °C / 15201 Torr 2.1: water; sodium nitrite; hydrogenchloride / acetonitrile / 0.67 h / 0 °C 2.2: 0.25 h / 0 °C / |Inert atmosphere 3.1: sodium hydroxide; water / methanol / 1.5 h / 20 °C View Scheme

sulfuric acid; sodium nitrite in water; isopropyl alcohol Product distribution / selectivity;

dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine T=100°C; P=15201 Torr; 36 h;