4-氨基-3-(三氟甲氧基)苯甲酸合成路线 （共 8 条）
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; 0.166667 h; 2: With copper(I) bromide in water T=0 - 100°C; 0.833333 h;
参考文献
WO2008/30520 A1, ;
Page/Page column 135-136 ;
WO 2008/030520 A1
反应条件
1.1: thionyl chloride / 3 h / 0 °C / Reflux 2.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 5 °C 2.2: 1.08 h 3.1: sodium hydroxide; ethanol / 2 h / 20 °C 3.2: pH 3 View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; SCHULZE, Volker; KOSEMUND, Dirk; WENGNER, Antje, Margret; SIEMEISTER, Gerhard; STOeCKIGT, Detlef; LIENAU, Philip; BRIEM, Hans
Patent: WO2012/160029 A1, 2012 ;
WO 2012/160029 A1
反应条件
thionyl chloride T=0°C; 3 h; Reflux;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; SCHULZE, Volker; KOSEMUND, Dirk; WENGNER, Antje, Margret; SIEMEISTER, Gerhard; STOeCKIGT, Detlef; LIENAU, Philip; SCHIROK, Hartmut; BRIEM, Hans
Patent: WO2012/143329 A1, 2012 ;
Location in patent: Page/Page column 137-138 ;
WO 2012/143329 A1
反应条件
thionyl chloride in ethanol T=0°C; 3 h; Reflux;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; SCHULZE, Volker; KOSEMUND, Dirk; WENGNER, Antje, Margret; SIEMEISTER, Gerhard; STOeCKIGT, Detlef; LIENAU, Philip; BRIEM, Hans
Patent: WO2012/160029 A1, 2012 ;
Location in patent: Page/Page column 115-116 ;
WO 2012/160029 A1
反应条件
1: With hydrogenchloride; water; sodium nitrite
T=0°C; 0.333333 h;
2: With potassium iodide in water
T=0°C; 3 h;
参考文献
Caldarelli, Marina; Angiolini, Mauro; Disingrini, Teresa; Donati, Daniele; Guanci, Marco; Nuvoloni, Stefano; Posteri, Helena; Quartieri, Francesca; Silvagni, Marco; Colombo, Riccardo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4507 - 4511
反应条件
1: With thionyl chloride
Heating / reflux;
2: With sodium hydrogencarbonate in water
参考文献
McKinnell, Robert Murray; Long, Daniel D.
Patent: US2013/287731 A1, 2013 ;
Location in patent: Paragraph 0284; 0285 ;
反应条件
hydrogenchloride in 1,4-dioxane; methanol
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
反应条件
in tetrahydrofuran; methanol; hexane; ethyl acetate
参考文献
Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward
Patent: US2003/69284 A1, 2003 ;
US 20030069284 A1
